Introduction: Cutaneous T cell lymphomas (CTCL) are rare forms of non Hodgkin lymphoma. CTCL disease stage is a key indicator of patient outcomes, and presence of peripheral blood involvement is a particularly important predictor of survival rates and disease progression. Since the characteristics of CTCL presentation vary regionally, it is important to report emerging trends to inform clinical best practice. Objectives: To identify trends in CTCL presentation in Kuwait. Methods: Clinical characteristics of CTCL patients who presented to the Kuwait Cancer Control Center between January 2019 and December 2023 were assessed. Diagnosis of CTCL was performed in accordance with WHO EORTC guidelines. Results: Of the 92 cases included in the cohort, 94% were diagnosed with mycosis fungoides (MF), while 3% had Sézary syndrome. The overall annual incidence rate of MF in Kuwait was estimated to be 0.39/100,000/year. The median age of the cohort was 40.5 years. B1 blood involvement was observed in 44.6% of all patients, and 53.1% of B1 patients were aged 19–40 years. Overall, 81.6% presented with early stage disease, and B1 blood involvement was observed in 28% of stage IA, 38% of stage IB, and 75% of stage IIA patients. Among patients with early skin involvement, 32.0% of T1 and 50.0% of T2 patients had B1 blood involvement. Conclusions: Our data suggest a young median age at presentation and high levels of blood involvement among early stage CTCL patients in Kuwait, over twice the levels reported in large international registries. This represents a potentially significant clinical feature of CTCL in Kuwait.
