Abstracts Archive

A 69-year-old male presented with a 5-month history of pruritus and lymphocytosis. The exam revealed a 5 cm purple nodule on the left axilla, and pink papules and plaques on the back. Punch biopsies showed dense dermal infiltrates of atypical CD4+, PD1+, and GATA3+ T-cells with intraepidermal and fo...

Introduction:Mycosis Fungoides/Sézary Syndrome (MF/SS) are primary cutaneous T-cell lymphomas (CTCLs) characterized by cutaneous involvement by clonal CD4+ mature T cells. Many patients with advanced disease develop circulating tumor cells, and even low levels of blood involvement (<250 clonal t...

BackgroundAvailable methods for MRD detection in CTCL utilize primarily circulating cellular DNA, and sensitivity of MRD in cfDNA has been poorly characterized for CTCL.  Genomic heterogeneity of CTCL limits the utility of disease-specific MRD panels, and existing hybrid capture based cell-free...

Introduction:Early relapse after stem cell transplantation (SCT) remains common in PTCL. Improved biomarkers may better select patients for SCT in PTCL.  Molecular residual disease (MRD) can inform decisions around SCT, but its utility is limited by confounding clonal hematopoiesis mutations, a...

Aim: Large cell transformation of mycosis fungoides (LCTMF) is frequently associated with more aggressive clinical course and inferior survival than classical MF. Yet, LCTMF is not recognised in current staging systems. Herein, we describe characteristics, management and outcomes of p...

Introduction:Human T cell leukaemia virus type 1 (HTLV-1) is the most potent viral driver of cancer in humans, causing adult T cell leukaemia/lymphoma (ATL) in 5% of carriers. We developed a method to detect 'ATL-like' hyper-expanded T cell clones circulating in the blood of HTLV-1 carriers with no ...

Background:Although many patients with Large granular lymphocytic leukemia present with cytopenias at diagnosis, the necessity for targeted treatment is not universally indicated. The diagnostic landscape is complicated by the coexistence of factors including autoimmune conditions, clonal hematopoie...

T-prolymphocytic leukemia (TPLL) is a rare, poor-prognostic, mature T-cell malignancy associated with an aggressive clinical course in the context of limited therapeutic options. Despite exponentially rising tumor burden, mainly in blood, bone marrow, and spleen, we discovered that many TPLL patient...

Recurrent mutations in enhancers (E) and super-enhancers (SE) contribute to lymphoma tumorigenesis, but their mutational landscape, targets, and functional impact in PTCL remain undefined.Using CUT&RUN (H3K27ac and H3K27me3 marks) and RNA-seq, we mapped the epigenetic landscape of 29 PTCL cell l...

Introduction CHOP are mostly planned as the first line therapy for PTCL patients. However, in the current modes of treatment strategy, a high incidence of relapse/disease progression/death was observed in PTCL patients. Methods 64 newly diagnosed PTCL patients (25 AITL, 17 PTCL NOS, 11 ALK ALCL and ...

Introduction:  Folliculotropic mycosis fungoides (FMF) is an aggressive variant of mycosis fungoides (MF). Malignant FMF T-cells localize to the pilosebaceous unit while malignant T-cells in classic MF (CMF) infiltrate the de...

Background: Circulating EBVDNA is an important biomarker for ENKTL, which is not just from tumor cells. Tumor cell derived EBVDNA is usually CpG methylated, so detection of methylated EBVDNA may improve its accuracy as a tumor biomarker. Aim: To explore the prognostic value of circulating cell free ...

IntroductionMonomorphic epitheliotropic intestinal T-cell lymphoma (MEITL) is an aggressive lymphoma with occasional multifocality. Methods, ObjectivesWe retrospectively investigated the clinicopathologic characteristics of MEITL patients, with a focus on multifocality and p...

Introduction:T-cell lymphoma (TCL) derived from CAR-T cells is a rare event (2 cases reported) in multiple myeloma (MM) patients receiving ciltacabtagene autoleucel (cilta-cel). Here, we present an enterotropic CAR+TCL post-cilta-cel, with unique genomic features.Methods: The presence of CAR+ c...

Natural Killer Large Granular Lymphocyte Leukemia (NK-LGLL) is a distinct LGLL subtype, accounting for 10-15% of LGLL cases. We present the first multimodal single-cell analysis of NK-LGLL in peripheral blood mononuclear cells from six patients and four healthy donors. We found that leukemic NK cell...

T-cell large granular lymphocyte leukemia (T-LGLL) is characterized by a clonal expansion of cytotoxic CD8+ T-cells. The pathogenesis of LGLL is not fully understood, and with no FDA-approved therapies, there is a need for a deeper understanding of the disease's molecular complexities and impact on ...

Background: Several B-cell malignancies  present evidence of stereotyped B-cell receptors and antigen driven pathogenesis. By contrast, this phenomenon has not been documented in T-cell lymphomas (TCL), an heterogeneous group of aggressive malignancies. Objective: This study aims to assess...